Journal Articles

 

253. Wei Z, Li Y, Hou X, Han Z, Xu J, McMahon MT, Duan W, Liu G, Lu H. Quantitative cerebrovascular reactivity MRI in mice using acetazolamide challenge. Magn Reson Med. 2022 Nov;88(5):2233-2241.

252. Lin Z, Jiang D, Liu P, Ge Y, Moghekar A, Lu H, Blood-brain barrier permeability in response to caffeine challenge. Magn Reson Med. 2022 Nov;88(5):2259-2266.

251. Hui SCN, Muhammad GS, Zöllner HJ, Oeltzschner G, Fan H, Li Y, Song Y, Jiang H, Near J, Lu H, Mori S, Edden REA. MRSCloud: a Cloud-based MR Spectroscopy Tool for Basis Set Simulation. Magn Reson Med. 2022 Nov;88(5):1994-2004.

250. Rajasekaran K, Ma Q, Good LB, Kathote G, Jakkamsetti V, Liu P, Avila A, Primeaux S, Enciso Alva J, Markussen KH, Marin-Valencia I, Sirsi D, Hacker PMS, Gentry MS, Su J, Lu H, Pascual JM. Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency. Sci Transl Med. 2022 Oct 5;14(665):eabn2956.

249. Liu P, Baker Z, Li Y, Li Y, Xu J, Park DC, Welch BG, Pinho M, Pillai JJ, Hillis AE, Mori S, Lu H. CVR-MRICloud: An online processing tool for CO2-inhalation and resting-state cerebrovascular reactivity (CVR) MRI data. PLoS One. 2022 Sep 28;17(9):e0274220. 

248. Clement P, Castellaro M, Okell T, Thomas D, Vandemaele P, Elgayar S, Oliver-Taylor A, Kirk T, Woods J, Vos S, Kuijer J, Achten E, van Osch M, Appelhoff S Blair R, Feingold F, Gau R, Markiewicz C, Salo T, Detre J, Lu H, Alsop D, Chappell M, Hernandez-Garcia L, Petr J, Mutsaerts H. ASL-BIDS, the brain imaging data structure extension for arterial spin labeling. Sci Data. 2022 Sep 6;9(1):543.

247. Jiang D, Lu H. Cerebral oxygen extraction fraction MRI: Techniques and applications. Magn Reson Med. 2022 Aug;88(2):575-600.

246. Bu X, Gao Y, Liang K, Bao W, Chen Y, Guo L, Gong Q, Lu H, Caffo B, Mori S, Huang X. Multivariate associations between behavioural dimensions and white matter across children and adolescents with and without attention-deficit/hyperactivity disorder. J Child Psychol Psychiatry. 2022 Aug 24. doi: 10.1111/jcpp.13689.

245. Soldan A, Alfini A, Pettigrew C, Faria A, Hou X, Lim C, Lu H, Spira AP, Zipunnikov V, Albert M; BIOCARD Research Team. Actigraphy-estimated physical activity is associated with functional and structural brain connectivity among older adults. Neurobiol Aging. 2022 Aug;116:32-40.

244. Guo Y, Cho SM, Wei Z, Wang Q, Modi HR, Gharibani P, Lu H, Thakor NV, Geocadin RG. Early Thalamocortical Reperfusion Leads to Neurologic Recovery in a Rodent Cardiac Arrest Model. Neurocrit Care. 2022 Aug;37(1):60-72.

243. Yedavalli VS, Hamam O, Bahouth M, Urrutia VC, Ahmed A, Lu H, Jones C, Luna LP, Sair HI, Lanzman B. Arterial Spin Labeling Imaging Characteristics of Anti-leucine-rich Glioma-Inactivated 1 Encephalitis: A Qualitative and Quantitative Analysis. Front Neurol. 2022 Jul 28;13:850029. 

242. Lin Z, Lim C, Jiang D, Soldan A, Pettigrew C, Oishi K, Liu P, Albert M, Lu H. Longitudinal changes in brain oxygen extraction fraction (OEF) in older adults: relationship to markers of vascular and Alzheimer's pathology. Alzheimers Dement. 2022 Jul 6. doi: 10.1002/alz.12727.

241. Alm KH, Soldan A, Pettigrew C, Faria AV, Hou X, Lu H, Moghekar A, Mori S, Albert M, Bakker A. Structural and functional connectivity measures uniquely contribute to episodic memory performance in older adults. Front Aging Neurosci. 2022 Jul 12;14:951076.

240. Fan H, Su P, Lin DDM, Goldberg EB, Walker A, Leigh R, Hillis AE, Lu H. Simultaneous Hemodynamic and Structural Imaging of Ischemic Stroke With Magnetic Resonance Fingerprinting Arterial Spin Labeling. StrokeStroke. 2022 Jun;53(6):2016-2025. 

239. Su P, Liu P, Pinho MC, Thomas BP, Qiao Y, Huang J, Welch BG, Lu H. Non-contrast hemodynamic imaging of Moyamoya disease with MR fingerprinting ASL: A feasibility study. Magn Reson Imaging. 2022;88:116-122.

238. Deckers PT, Bhogal AA, Dijsselhof MB, Faraco CC, Liu P, Lu H, Donahue MJ, Siero JC. Hemodynamic and metabolic changes during hypercapnia with normoxia and hyperoxia using pCASL and TRUST MRI in healthy adults. J Cereb Blood Flow Metab. 2022;42(5):861-875.

237. Lin Z, Lance E, McIntyre T, Li Y, Liu P, Lim C, Fan H, Tekes A, Cannon A, Casella JF, Lu H. Imaging Blood-Brain Barrier Permeability Through MRI in Pediatric Sickle Cell Disease: A Feasibility Study. J Magn Reson Imaging. 2022;55(5):1551-1558.

236. Xu M, Bo B, Pei M, Chen Y, Shu CY, Qin Q, Hirschler L, Warnking JM, Barbier EL, Wei Z, Lu H, Herman P, Hyder F, Liu ZJ, Liang Z, Thompson GJ. High-resolution relaxometry-based calibrated fMRI in murine brain: Metabolic differences between awake and anesthetized states. J Cereb Blood Flow Metab. 2022;42(5):811-825.

235. Sun Z, Jiang D, Liu P, Muccio M, Li C, Cao Y, Wisniewski TM, Lu H, Ge Y. Age-related Tortuosity of Carotid and Vertebral Arteries: Quantitative Evaluation with MR Angiography. Front Neurol. 2022;13:858805.

234. Deng S, Franklin CG, O'Boyle M, Zhang W, Heyl BL, Jerabek PA, Lu H, Fox PT. Hemodynamic and metabolic correspondence of resting-state voxel-based physiological metrics in healthy adults. Neuroimage. 2022;250:118923.

233. Turner MP, Zhao Y, Abdelkarim D, Liu P, Spence JS, Hutchison JL, Sivakolundu DK, Thomas BP, Hubbard NA, Xu C, Taneja K, Lu H, Rypma B. Altered linear coupling between stimulus-evoked blood flow and oxygen metabolism in the aging human brain. Cereb Cortex. 2022 Apr 7:bhac057.

232. Maillard P, Lu H, Arfanakis K, Gold BT, Bauer CE, Zachariou V, Stables L, Wang DJJ, Jann K, Seshadri S, Duering M, Hillmer LJ, Rosenberg GA, Snoussi H, Sepehrband F, Habes M, Singh B, Kramer JH, Corriveau RA, Singh H, Schwab K, Helmer KG, Greenberg SM, Caprihan A, DeCarli C, Satizabal CL; MarkVCID Consortium. Instrumental validation of free water, peak-width of skeletonized mean diffusivity, and white matter hyperintensities: MarkVCID neuroimaging kits. Alzheimers Dement (Amst). 2022;14(1):e12261.

231. Weinstein JD, Hamam O, Urrutia VC, Lu H, Luna LP, Tekes-Brady A, Bahouth M, Yedavalli V. Added Value of Arterial Spin Labeling in Detecting Posterior Reversible Encephalopathy Syndrome as a Stroke Mimic on Baseline Neuroimaging: A Single Center Experience. Front Neurol. 2022;13:831218.

230. Han H, Lin Z, Soldan A, Pettigrew C, Betz JF, Oishi K, Li Y, Liu P, Albert M, Lu H. Longitudinal Changes in Global Cerebral Blood Flow in Cognitively Normal Older Adults: A Phase-Contrast MRI Study. J Magn Reson Imaging. 2022 Feb 26. doi: 10.1002/jmri.28133.

229. Afthinos A, Themistocleous C, Herrmann O, Fan H, Lu H, Tsapkini K. The Contribution of Working Memory Areas to Verbal Learning and Recall in Primary Progressive Aphasia. Front Neurol. 2022;13:698200.

228. Lin Z, McIntyre T, Jiang D, Cannon A, Liu P, Tekes A, Casella JF, Slifer K, Lu H, Lance E. Brain Oxygen Extraction and Metabolism in Pediatric Patients With Sickle Cell Disease: Comparison of Four Calibration Models. Front Physiol. 2022;13:814979.

227. Qi Y, Lin Z, Lu H, Zhao P, Hou Y, Mao J. The Association Between Pregnancy-Induced Hypertension and Neonatal Cerebral Metabolism, Hemodynamics, and Brain Injury as Determined by Physiological Imaging. Front Physiol. 2022;13:756386.

226. Sexton CE, Anstey KJ, Baldacci F, Barnum CJ, Barron AM, Blennow K, Brodaty H, Burnham S, Elahi FM, Götz J, Jeon YH, Koronyo-Hamaoui M, Landau SM, Lautenschlager NT, Laws SM, Lipnicki DM, Lu H, Masters CL, Moyle W, Nakamura A, Pasinetti GM, Rao N, Rowe C, Sachdev PS, Schofield PR, Sigurdsson EM, Smith K, Srikanth V, Szoeke C, Tansey MG, Whitmer R, Wilcock D, Wong TY, Bain LJ, Carrillo MC. Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney. Alzheimers Dement. 2022;18(1):178-190.

225. Liu P, Jiang D, Albert M, Bauer CE, Caprihan A, Gold BT, Greenberg SM, Helmer KG, Jann K, Jicha G, Rodriguez P, Satizabal CL, Seshadri S, Singh H, Thompson JF, Wang DJJ, Lu H. Multi-vendor and multisite evaluation of cerebrovascular reactivity mapping using hypercapnia challenge. Neuroimage. 2021;245:118754.

224. Liu H, Zhang C, Xu J, Jin J, Cheng L, Miao X, Wu Q, Wei Z, Liu P, Lu H, van Zijl PCM, Ross CA, Hua J, Duan W. Huntingtin silencing delays onset and slows progression of Huntington's disease: a biomarker study. Brain. 2021;144(10):3101-3113.

223. Li Y, Lim C, Schär M, Jiang D, Qiao Y, Pillai JJ, Lu H. Three-dimensional assessment of brain arterial compliance: Technical development, comparison with aortic pulse wave velocity, and age effect. Magn Reson Med. 2021;86(4):1917-1928.

222. Soldan A, Pettigrew C, Zhu Y, Wang MC, Bilgel M, Hou X, Lu H, Miller MI, Albert M; BIOCARD Research Team. Association of Lifestyle Activities with Functional Brain Connectivity and Relationship to Cognitive Decline among Older Adults. Cereb Cortex. 2021;31(12):5637-5651.

221. Jiang D, Koehler RC, Liu X, Kulikowicz E, Lee JK, Lu H, Liu P. Quantitative validation of MRI mapping of cerebral venous oxygenation with direct blood sampling: A graded-O2 study in piglets. Magn Reson Med. 2021;86(3):1445-1453.

220. Xu F, Zhu D, Fan H, Lu H, Liu D, Li W, Qin Q. Magnetic resonance angiography and perfusion mapping by arterial spin labeling using Fourier transform-based velocity-selective pulse trains: Examination on a commercial perfusion phantom. Magn Reson Med. 2021;86(3):1360-1368.

219. Wei Z, Xu J, Chen L, Hirschler L, Barbier EL, Li T, Wong PC, Lu H. Brain metabolism in tau and amyloid mouse models of Alzheimer's disease: An MRI study. NMR Biomed. 2021;34(9):e4568.

218. Chen L, van Zijl PCM, Wei Z, Lu H, Duan W, Wong PC, Li T, Xu J. Early detection of Alzheimer's disease using creatine chemical exchange saturation transfer magnetic resonance imaging. Neuroimage. 2021;236:118071.

217. Lin Z, Sur S, Liu P, Li Y, Jiang D, Hou X, Darrow J, Pillai JJ, Yasar S, Rosenberg P, Albert M, Moghekar A, Lu H. Blood-Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease. Ann Neurol. 2021;90(2):227-238.

216. Zhao Y, Liu P, Turner MP, Abdelkarim D, Lu H, Rypma B. The neural-vascular basis of age-related processing speed decline. Psychophysiology. 2021;58(7):e13845.

215. Lin Z, Jiang D, Liu D, Li Y, Uh J, Hou X, Pillai JJ, Qin Q, Ge Y, Lu H. Noncontrast assessment of blood-brain barrier permeability to water: Shorter acquisition, test-retest reproducibility, and comparison with contrast-based method. Magn Reson Med. 2021;86(1):143-156.

214. Chen L, Wei Z, Chan KW, Li Y, Suchal K, Bi S, Huang J, Xu X, Wong PC, Lu H, van Zijl PC, Li T, Xu J. D-Glucose uptake and clearance in the tauopathy Alzheimer's disease mouse brain detected by on-resonance variable delay multiple pulse MRI. J Cereb Blood Flow Metab. 2021;41(5):1013-1025.

213. Lu D, Li Y, Lu H, Pillai JJ. Histogram-based analysis of cerebral blood flow using arterial spin labeling MRI in de novo brain gliomas: relationship to histopathologic grade and molecular markers. Neuroradiology. 2021 May;63(5):751-760. 

212. Hubbard NA, Turner MP, Sitek KR, West KL, Kaczmarzyk JR, Himes L, Thomas BP, Lu H, Rypma B. Resting cerebral oxygen metabolism exhibits archetypal network features. Hum Brain Mapp. 2021;42(7):1952-1968.

211. Liu P, Liu G, Pinho MC, Lin Z, Thomas BP, Rundle M, Park DC, Huang J, Welch BG, Lu H. Cerebrovascular Reactivity Mapping Using Resting-State BOLD Functional MRI in Healthy Adults and Patients with Moyamoya Disease. Radiology. 2021;299(2):419-425.

210. Lu H, Kashani AH, Arfanakis K, Caprihan A, DeCarli C, Gold BT, Li Y, Maillard P, Satizabal CL, Stables L, Wang DJJ, Corriveau RA, Singh H, Smith EE, Fischl B, van der Kouwe A, Schwab K, Helmer KG, Greenberg SM; MarkVCID Consortium. MarkVCID cerebral small vessel consortium: II. Neuroimaging protocols. Alzheimers Dement. 2021 Apr;17(4):716-725.

209. Fan H, Su P, Huang J, Liu P, Lu H. Multi-band MR fingerprinting (MRF) ASL imaging using artificial-neural-network trained with high-fidelity experimental data. Magn Reson Med. 2021 Apr;85(4):1974-1985.

208. West KL, Sivakolundu DK, Zuppichini MD, Spence JS, Lu H, Okuda DT, Rypma B. Altered Cerebral Blood Flow and Oxygen Metabolism Underlies Motor Impairment in Multiple Sclerosis. J Cereb Blood Flow Metab. 2021 Jan;41(1):182-193.

207. Jiang D, Deng S, Franklin CG, O'Boyle M, Zhang W, Heyl BL, Pan L, Jerabek PA, Fox PT, Lu H. Validation of T2 -based oxygen extraction fraction measurement with 15 O positron emission tomography. Magn Reson Med. 2021 Jan;85(1):290-297.

206. Jiang D, Lin Z, Liu P, Sur S, Xu C, Hazel K, Pottanat G, Darrow J, Pillai JJ, Yasar S, Rosenberg P, Moghekar A, Albert M, Lu H. Brain Oxygen Extraction Is Differentially Altered by Alzheimer's and Vascular Diseases. J Magn Reson Imaging. 2020;52(6):1829-1837.

205. Ning B, Guo G, Gu C, Xu J, Bibic A, He X, Liu H, Chen L, Wei Z, Duan W, Liu P, Lu H, van Zijl PCM, Ross CA, Smith W, Hua J. Mutant G2019S-LRRK2 Induces Abnormalities in Arteriolar Cerebral Blood Volume in Mouse Brains: An MRI Study. Neurodegener Dis. 2020:1-8.

204. Tarumi T, Thomas BP, Tseng BY, Wang C, Womack KB, Hynan L, Lu H, Cullum CM, Zhang R. Cerebral White Matter Integrity in Amnestic Mild Cognitive Impairment: A 1-Year Randomized Controlled Trial of Aerobic Exercise Training. J Alzheimers Dis. 2020;73(2):489-501.

203. Wei Z, Wang Q,  ZModi HR, Cho SM, Geocadin R, Thakor NV, Lu H. Acute-stage MRI cerebral oxygen consumption biomarkers predict 24-hour neurological outcome in a rat cardiac arrest model. NMR Biomed. 2020;33(11):e4377.

202. Sivakolundu DK, West KL, Maruthy GB, Zuppichini M, Turner MP, Abdelkarim D, Zhao Y, Nguyen D, Spence JS, Lu H, Okuda DT, Rypma B. Reduced arterial compliance along the cerebrovascular tree predicts cognitive slowing in multiple sclerosis: Evidence for a neurovascular uncoupling hypothesis. Mult Scler. 2020;26(12):1486-1496.

201. Zhang Q, Su P, Chen Z, Liao Y, Chen S, Guo R, Qi H, Li X, Zhang X, Hu Z, Lu H, Chen H. Deep learning-based MR fingerprinting ASL ReconStruction (DeepMARS). Magn Reson Med. 2020;84(2):1024-1034.

200. Ashimatey BS, D'Orazio LM, Ma SJ, Jann K, Jiang X, Lu H, Wang DJJ, Ringman JM, Kashani AH. Lower retinal capillary density in minimal cognitive impairment among older Latinx adults. Alzheimers Dement (Amst). 2020;12(1):e12071.

199. Sur S, Lin Z, Li Y, Yasar S, Rosenberg P, Moghekar A, Hou X, Kalyani R, Hazel K, Pottanat G, Xu C, van Zijl P, Pillai J, Liu P, Albert M, Lu H. Cerebrovascular reactivity predicts cognitive performance independent of Alzheimer pathology. Neurology, Neurology. 2020;95(8):e962-e972.

198. Zhang Q, Su P, Chen Z, Liao Y, Chen S, Guo R, Qi H, Li X, Zhang X, Hu Z, Lu H, Chen H. Deep Learning based MR Fingerprinting ASL ReconStruction (DeepMARS). Magn Reson Med. 2020;84(2):1024-1034.

197. Chen L, Wei Z, Chan KW, Li Y, Suchal K, Bi S, Huang J, Xu X, Wong PC, Lu H, van Zijl PC, Li T, Xu J. D-Glucose uptake and clearance in the tauopathy Alzheimer's disease mouse brain detected by on-resonance variable delay multiple pulse MRI. J Cereb Blood Flow Metab. 2020:271678X20941264.

196. Taneja K, Liu P, Xu C, Turner M, Zhao Y, Abdelkarim D, Thomas BP, Rypma B, Lu H. Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI. Front Neurol. 2020;11:758.

195. Thomas BP, Tarumi T, Sheng M, Tseng B, Womack KB, Munro Cullum C, Rypma B, Zhang R, Lu H. Brain Perfusion Change in Patients with Mild Cognitive Impairment After 12 Months of Aerobic Exercise Training. J Alzheimers Dis. 2020;75(2):617-631.

194. Liu P, Xu C, Lin Z, Sur S, Li Y, Yasar S, Rosenberg P, Albert M, Lu H. Cerebrovascular reactivity mapping using intermittent breath modulation. Neuroimage. 2020;215:116787

193. Walker KA, Gross AL, Moghekar AR, Soldan A, Pettigrew C, Hou X, Lu H, Alfini AJ, Bilgel M, Miller MI, Albert MS, Walston J. Association of peripheral inflammatory markers with connectivity in large-scale functional brain networks of non-demented older adults. Brain Behav Immun. 2020;87:388-396.

192. Wei Z, Chen L, Hou X, van Zijl PCM, Xu J, Lu H. Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study. Front Neurol. 2020;11:559.

191. Lewis N, Lu H, Liu P, Hou X, Damaraju E, Iraji A, Calhoun V. Static and Dynamic Functional Connectivity Analysis of Cerebrovascular Reactivity: An fMRI Study. Brain and Behavior. 2020;10(6):e01516.

190. Sivakolundu DK, West KL, Zuppichini M, Turner MP, Abdelkarim D, Zhao Y, Spence JS, Lu H, Okuda DT, Rypma B. The neurovascular basis of processing speed differences in humans: A model-systems approach using multiple sclerosis. Neuroimage. 2020;215:116812.

189. Li W, Xu X, Liu P, Strouse JJ, Casella JF, Lu H, van Zijl PCM, Qin Q. Quantification of whole-brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T2 -based oxygenation calibrations. Magn Reson Med. 2020;83(3):1066-1080.

188. Chen L, Schär M, Chan KWY, Huang J, Wei Z, Lu H, Qin Q, Weiss RG, van Zijl PCM, Xu J. In vivo imaging of phosphocreatine with artificial neural networks. Nat Commun. 2020;11(1):1072.

187. Tarumi T, Thomas BP, Tseng BY, Wang C, Womack KB, Hynan L, Lu H, Cullum CM, Zhang R. Cerebral White Matter Integrity in Amnestic Mild Cognitive Impairment: A 1-Year Randomized Controlled Trial of Aerobic Exercise Training. J Alzheimers Dis. 2020;73(2):489-501.

186. Hou X, Liu P, Li Y, Jiang D, De Vis JB, Lin Z, Sur S, Baker Z, Mao D, Ravi H, Rodrigue K, Albert M, Park DC, Lu H. The association between BOLD-based cerebrovascular reactivity (CVR) and end-tidal CO2 in healthy subjects. Neuroimage. 2020;207:116365.

185. Dodd AB, Lu H, Wertz CJ, Ling JM, Shaff NA, Wasserott BC, Meier TB, Park G, Oglesbee SJ, Phillips JP, Campbell RA, Liu P, Mayer AR. Persistent alterations in cerebrovascular reactivity in response to hypercapnia following pediatric mild traumatic brain injury. J Cereb Blood Flow Metab. 2020:271678X19896883.

184. Su P, Fan H, Liu P, Li Y, Qiao Y, Hua J, Lin D, Jiang D, Pillai JJ, Hillis AE, Lu H. MR fingerprinting ASL: Sequence characterization and comparison with dynamic susceptibility contrast (DSC) MRI. NMR Biomed. 2020;33(1):e4202.

183. Abdelkarim D, Zhao Y, Turner MP, Sivakolundu DK, Lu H, Rypma B. A neural-vascular complex of age-related changes in the human brain: Anatomy, physiology, and implications for neurocognitive aging. Neurosci Biobehav Rev. 2019;107:927-944.

182. Chen L, Wei Z, Cai S, Li Y, Liu G, Lu H, Weiss RG, van Zijl PCM, Xu J. High-resolution creatine mapping of mouse brain at 11.7 T using non-steady-state chemical exchange saturation transfer. NMR Biomed. 2019;32(11):e4168.

181. Karthikeyan S, Fiksenbaum L, Grigorian A, Lu H, MacIntosh BJ, Goldstein BI. Normal Cerebral Oxygen Consumption Despite Elevated Cerebral Blood Flow in Adolescents With Bipolar Disorder: Putative Neuroimaging Evidence of Anomalous Energy Metabolism. Front Psychiatry. 2019;10:739.

180. Tarumi T, Rossetti H, Thomas BP, Harris T, Tseng BY, Turner M, Wang C, German Z, Martin-Cook K, Stowe AM, Womack KB, Mathews D, Kerwin DR, Hynan L, Diaz-Arrastia R, Lu H, Cullum CM, Zhang R. Exercise Training in Amnestic Mild Cognitive Impairment: A One-Year Randomized Controlled Trial. J Alzheimers Dis. 2019;71(2):421-433.

179. Jiang D, Lu H, Parkinson C, Su P, Wei Z, Li P, Tekes A, Huisman TAGM, Golden WC, Liu P. Vessel-specific quantification of neonatal cerebral venous oxygenation. Magn Reson Med. 2019;82(3):1129-1139.

178. Cooper C, Fatt CC, Liu P, Grannemann B, Almeida J, Deckersbach T, Fava M, Kurian B, Malchow A, McGrath P, McInnis M, Oquendo M, Parsey R, Bartlett E, Weissman M, Philips M, Lu H, Carmody T, Trivedi M. Discovery and replication of cerebral blood flow differences in major depressive disorder. Mol Psychiatry. 2020;25(7):1500-1510.

177. Jiang D, Lin Z, Liu P, Sur S, Xu C, Hazel K, Pottanat G, Yasar S, Rosenberg P, Albert M, Lu H. Normal variations in brain oxygen extraction fraction are partly attributed to differences in end-tidal CO2. J Cereb Blood Flow Metab. 2020;40(7):1492-1500.

176. Samudra N, Motes M, Lu H, Sheng M, Diaz-Arrastia R, Devous M, Hart J, Womack KB. A Pilot Study of Changes in Medial Temporal Lobe Fractional Amplitude of Low Frequency Fluctuations after Sildenafil Administration in Patients with Alzheimer's Disease. J Alzheimers Dis. 2019;70(1):163-170.

175. Lin Z, Sur S, Soldan A, Pettigrew C, Miller M, Oishi K, Bilgel M, Moghekar A, Pillai JJ, Albert M, Lu H. Brain oxygen extraction by MRI in older individuals: relationship to Apolipoprotein E genotype and amyloid burden. Radiology. 2019;292(1):140-148.

174. Soldan A, Moghekar A, Walker KA, Pettigrew C, Hou X, Lu H, Miller MI, Alfini A, Albert M, Xu D, Xiao MF, Worley P; BIOCARD Research Team. Resting-State Functional Connectivity Is Associated With Cerebrospinal Fluid Levels of the Synaptic Protein NPTX2 in Non-demented Older Adults. Front Aging Neurosci. 2019;11:132.

173. Cooper CM, Chin Fatt CR, Jha M, Fonzo GA, Grannemann BD, Carmody T, Ali A, Aslan S, Almeida JRC, Deckersbach T, Fava M, Kurian BT, McGrath PJ, McInnis M, Parsey RV, Weissman M, Phillips ML, Lu H, Etkin A, Trivedi MH. Cerebral Blood Perfusion Predicts Response to Sertraline versus Placebo for Major Depressive Disorder in the EMBARC Trial. EClinicalMedicine. 2019;10:32-41.

172. Hua J, Lee S, Blair NIS, Wyss M, van Bergen JMG, Schreiner SJ, Kagerer SM, Leh SE, Gietl AF, Treyer V, Buck A, Nitsch RM, Pruessmann KP, Lu H, Van Zijl PCM, Albert M, Hock C, Unschuld PG. Increased cerebral blood volume in small arterial vessels is a correlate of amyloid-β-related cognitive decline. Neurobiol Aging. 2019;76:181-193.

171. Agarwal S, Sair HI, Gujar S, Hua J, Lu H, Pillai JJ. Functional Magnetic Resonance Imaging Activation Optimization in the Setting of Brain Tumor-Induced Neurovascular Uncoupling Using Resting-State Blood Oxygen Level-Dependent Amplitude of Low Frequency Fluctuations. Brain Connect. 2019;9(3):241-250.

170. Wei Z, Chen L, Lin Z, Jiang D, Xu J, Liu P, van Zijl PCM, Lu H. Optimization of phase-contrast MRI for the estimation of global cerebral blood flow of mice at 11.7T. Magn Reson Med. 2019;81(4):2566-2575.

169. Chen L, Wei Z, Chan KWY, Cai S, Liu G, Lu H, Wong PC, van Zijl PCM, Li T, Xu J. Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI. Neuroimage. 2019;188:380-390.

168. Taneja K, Lu H, Welch BG, Thomas BP, Pinho M, Lin D, Hillis AE, Liu P. Evaluation of cerebrovascular reserve in patients with cerebrovascular diseases using resting-state MRI: A feasibility study. Magn Reson Imaging. 2019;59:46-52.

167. Li Y, Liu P, Li Y, Fan H, Su P, Peng SL, Park DC, Rodrigue KM, Jiang H, Faria AV, Ceritoglu C, Miller M, Mori S, Lu H. ASL-MRICloud: An online tool for the processing of ASL MRI data. NMR Biomed. 2019;32(2):e4051.

166.Shetty AN, Lucke AM, Liu P, Sanz Cortes M, Hagan JL, Chu ZD, Hunter JV, Lu H, Lee W, Kaiser JR. Cerebral oxygen metabolism during and after therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy: a feasibility study using magnetic resonance imaging. Pediatr Radiol. 2019;49(2):224-233.

165. Lu H. Physiological MRI of the brain: Emerging techniques and clinical applications. Neuroimage. 2019;187:1-2.

164. Hou X, Liu P, Gu H, Chan M, Li Y, Peng SL, Wig G, Yang Y, Park D, Lu H. Estimation of brain functional connectivity from hypercapnia BOLD MRI data: Validation in a lifespan cohort of 170 subjects. Neuroimage. 2019;186:455-463.

163. Liu P, JB De Vis, Lu H. Cerebrovascular reactivity (CVR) MRI with CO2 challenge: A technical review. Neuroimage. 2019;187:104-115.

162. Liu P, Qi Y, Lin Z, Guo Q, Wang X, Lu H. Assessment of cerebral blood flow in neonates and infants: A phase-contrast MRI study. Neuroimage. 2019;185:926-933.

161. Agarwal S, Hua J, Sair HI, Gujar S, Bettegowda C, Lu H, Pillai JJ. Repeatability of language fMRI lateralization and localization metrics in brain tumor patients. Hum Brain Mapp. 2018;39(12):4733-4742.

160. Shin SS, Krishnan V, Stokes W, Robertson C, Celnik P, Chen Y, Song X, Lu H, Liu P, Pelled G. Transcranial magnetic stimulation and environmental enrichment enhances cortical excitability and functional outcomes after traumatic brain injury. Brain Stimul. 2018;11(6):1306-1313.

159. Haber M, Amyot F, Kenney K, Meredith-Duliba T, Moore C, Silverman E, Podell J, Chou YY, Pham DL, Butman J, Lu H, Diaz-Arrastia R, Sandsmark D. Vascular Abnormalities within Normal Appearing Tissue in Chronic Traumatic Brain Injury. J Neurotrauma. 2018;35(19):2250-2258.

158. Lin Z, Li Y, Su P, Mao D, Wei Z, Pillai JJ, Moghekar A, van Osch M, Ge Y, Lu H. Non-contrast MR imaging of blood-brain barrier permeability to water. Magn Reson Med. 2018;80(4):1507-1520.

157. Li Y, Mao D, Li Z, Schär M, Pillai JJ, Pipe JG, Lu H. Cardiac-triggered pseudo-continuous arterial-spin-labeling: A cost-effective scheme to further enhance the reliability of arterial-spin-labeling MRI. Magn Reson Med. 2018;80(3):969-975.  

156. Jiang D, Liu P, Li Y, Mao D, Xu C, Lu H. Cross-vendor harmonization of T2 -relaxation-under-spin-tagging (TRUST) MRI for the assessment of cerebral venous oxygenation. Magn Reson Med. 2018;80(3):1125-1131.

155. Ding K, Tarumi T, Zhu DC, Tseng BY, Thomas BP, Turner M, Repshas J, Kerwin DR, Womack KB, Lu H, Cullum CM, Zhang R. Cardiorespiratory Fitness and White Matter Neuronal Fiber Integrity in Mild Cognitive Impairment. J Alzheimers Dis. 2018;61(2):729-739. 

154. De Vis JB, Peng SL, Chen X, Li Y, Liu P, Sur S, Rodrigue KM, Park DC, Lu H. Arterial-spin-labeling (ASL) perfusion MRI predicts cognitive function in elderly individuals: A 4-year longitudinal study. J Magn Reson Imaging. 2018;48(2):449-458.  

153. Wei Z, Xu J, Liu P, Chen L, Li W, van Zijl P, Lu H. Quantitative assessment of cerebral venous blood T2 in mouse at 11.7T: Implementation, optimization, and age effect. Magn Reson Med. 2018;80(2):521-528.  

152. Peng SL, Chen X, Li Y, Rodrigue KM, Park DC, Lu H. Age-related changes in cerebrovascular reactivity and their relationship to cognition: A four-year longitudinal study. Neuroimage 2018;174:257-262.

151. King KS, Sheng M, Liu P, Maroules CD, Rubin CD, Peshock RM, McColl RW, Lu H. Detrimental effect of systemic vascular risk factors on brain hemodynamic function assessed with MRI. Neuroradiol J. 2018;31(3):253-261.

150. Amyot F, Kenney K, Moore C, Haber M, Turtzo LC, Shenouda C, Silverman E, Gong Y, Qu BX, Harburg L, Lu H, Wassermann EM, Diaz-Arrastia R. Imaging of Cerebrovascular Function in Chronic Traumatic Brain Injury. J Neurotrauma. 2018;35(10):1116-1123.

149. De Vis JB, Lu H, Ravi H, Hendrikse J, Liu P. Spatial distribution of flow and oxygenation in the cerebral venous drainage system. J Magn Reson Imaging. 2018;47(4):1091-1098.

148. Qi Y, Liu P, Lin Z, Lu H, Wang X. Hemodynamic and Metabolic Assessment of Neonates With Punctate White Matter Lesions Using Phase-Contrast MRI and T2-Relaxation-Under-Spin-Tagging (TRUST) MRI. Front Physiol. 2018;9:233.

147. Kenney K, Amyot F, Moore C, Haber M, Turtzo LC, Shenouda C, Silverman E, Gong Y, Qu BX, Harburg L, Wassermann EM, Lu H, Diaz-Arrastia R. Phosphodiesterase-5 inhibition potentiates cerebrovascular reactivity in chronic traumatic brain injury. Ann Clin Transl Neurol. 2018;5(4):418-428. 

146. Mao D, Li Y, Liu P, Peng SL, Pillai JJ, Lu H. Three-dimensional mapping of brain venous oxygenation using R2* oximetry. Magn Reson Med. 2018;79(3):1304-1313.

145. Filbey FM, Aslan S, Lu H, Peng SL. Residual Effects of THC via Novel Measures of Brain Perfusion and Metabolism in a Large Group of Chronic Cannabis Users. Neuropsychopharmacology. 2018;43(4):700-707.

144. Stephens JA, Liu P, Lu H, Suskauer SJ. Cerebral Blood Flow after Mild Traumatic Brain Injury: Associations between Symptoms and Post-Injury Perfusion. J Neurotrauma. 2018;35(2):241-248.

143. Xu F, Li W, Liu P, Hua J, Strouse JJ, Pekar JJ, Lu H, van Zijl PCM, Qin Q. Accounting for the role of hematocrit in between-subject variations of MRI-derived baseline cerebral hemodynamic parameters and functional BOLD responses. Hum Brain Mapp. 2018;39(1):344-353.

142. Almeida JRC, Greenberg T, Lu H, Chase HW, Fournier JC, Cooper CM, Deckersbach T, Adams P, Carmody T, Fava M, Kurian B, McGrath PJ, McInnis MG, Oquendo MA, Parsey R, Weissman M, Trivedi M, Phillips ML. Test-retest reliability of cerebral blood flow in healthy individuals using arterial spin labeling: Findings from the EMBARC study. Magn Reson Imaging. 2018;45:26-33.

141. Zheng G, Lu H, Yu W, Luo S, Liu Y, Liu W, Liu H, Wu L, Zheng L, Kong X, Zhang LJ, Lu GM. Severity-specific alterations in CBF, OEF and CMRO2 in cirrhotic patients with hepatic encephalopathy. Eur Radiol. 2017;27(11):4699-4709. 

140. Hubbard NA, Turner MP, Ouyang M, Himes L, Thomas BP, Hutchison JL, Faghihahmadabadi S, Davis SL, Strain JF, Spence J, Krawczyk DC, Huang H, Lu H, Hart J Jr, Frohman TC, Frohman EM, Okuda DT, Rypma B. Calibrated imaging reveals altered grey matter metabolism related to white matter microstructure and symptom severity in multiple sclerosis. Hum Brain Mapp. 2017;38(11):5375-5390.

139. Su P, Mao D, Liu P, Li Y, Pinho MC, Welch BG, Lu H. Multiparametric estimation of brain hemodynamics with MR fingerprinting ASL. Magn Reson Med. 2017;78(5):1812-1823.

138. Gopal KV, Thomas BP, Nandy R, Mao D, Lu H. Potential Audiological and MRI Markers of Tinnitus. J Am Acad Audiol. 2017;28(8):742-757.

137. Agarwal S, Lu H, Pillai JJ. Value of Frequency Domain Resting-State Functional Magnetic Resonance Imaging Metrics Amplitude of Low-Frequency Fluctuation and Functional Amplitude of Low-Frequency Fluctuation in the Assessment of Brain Tumor-Induced Neurovascular Uncoupling. Brain Connect. 2017;7(6):382-389.

136. Ivleva EI, Clementz BA, Dutcher AM, Arnold SJ, Jeon-Slaughter H, Aslan S, Witte B, Poudyal G, Lu H, Meda SA, Pearlson GD, Sweeney JA, Keshavan MS, Tamminga CA. Brain Structure Biomarkers in the Psychosis Biotypes: Findings From the Bipolar-Schizophrenia Network for Intermediate Phenotypes. Biol Psychiatry. 2017;82(1):26-39.

135. Li W, Liu P, Lu H, Strouse JJ, van Zijl PC, Qin Q. Fast measurement of blood T1 in the human carotid artery at 3T: Accuracy, precision, and reproducibility. Magn Reson Med. 2017;77:2296-2302.  

134. Lu J, Duan Y, Zuo Z, Xu W, Zhang X, Li C, Xue R, Lu H, Zhang W. Depression in patients with SAPHO syndrome and its relationship with brain activity and connectivity. Orphanet J Rare Dis. 2017;12(1):103. 

133. Sheng M, Liu P, Mao D, Ge Y, Lu H. The impact of hyperoxia on brain activity: A resting-state and task-evoked electroencephalography (EEG) study. PLoS One. 2017;12:e0176610.  

132. Thomas BP, Sheng M, Tseng BY, Tarumi T, Martin-Cook K, Womack KB, Cullum MC, Levine BD, Zhang R, Lu H. Reduced global brain metabolism but maintained vascular function in amnestic mild cognitive impairment. J Cereb Blood Flow Metab. 2017;37:1508-1516.

131. Khan MA, Liu J, Tarumi T, Lawley J, Liu P, Zhu D, Lu H, Zhang R. Measurement of cerebral blood flow using phase contrast MRI and duplex ultrasonography. J Cereb Blood Flow Metab. 2017;37:541-549. 

130. Sheng M, Lu H, Liu P, Li Y, Ravi H, Peng SL, Diaz-Arrastia R, Devous MD, Womack KB. Sildenafil Improves Vascular and Metabolic Function in Patients with Alzheimer's Disease. J Alzheimers Dis. 2017;60(4):1351-1364.  

129. Ouyang M, Liu P, Jeon T, Chalak L, Heyne R, Rollins NK, Licht DJ, Detre JA, Roberts TP, Lu H, Huang H. Heterogeneous increases of regional cerebral blood flow during preterm brain development: Preliminary assessment with pseudo-continuous arterial spin labeled perfusion MRI. Neuroimage. 2017;147:233-242.

128. Peng S, Ravi H, Sheng M, Thomas BP, Lu H. Searching for a truly “iso-metabolic” gas challenge in physiological MRI. J Cereb Blood Flow Metab. 2017;37:715-725..

127. Liu P, Welch BG, Li Y, Gu H, King D, Yang Y, Pinho M, Lu H. Multiparametric imaging of brain hemodynamics and function using gas-inhalation MRI. Neuroimage. 2017;146:715-723.

126. Ouyang M, Liu P, Jeon T, Chalak L, Heyne R, Rollins NK, Licht DJ, Detre JA, Roberts TPL, Lu H, Huang H. Heterogeneous increases of regional cerebral blood flow during preterm brain development: Preliminary assessment with pseudo-continuous arterial spin labeled perfusion MRI. Neuroimage. 2017 Feb 15;147:233-242. doi: 10.1016/j.neuroimage.2016.12.034.  

126. Liu P, Li Y, Pinho M, Park DC, Welch BG, Lu H. Cerebrovascular reactivity mapping without gas challenges. Neuroimage. 2017;146:320-326  

125. Marshall O, Chawla S, Lu H, Pape L, Ge Y. Cerebral blood flow modulation insufficiency in brain networks in multiple sclerosis: a hypercapnia MRI study, J Cereb Blood Flow Metab. 2016 36:2087-2095.

124. Yu Y, Lee DH, Peng SL, Zhang K, Zhang Y, Jiang S, Zhao X, Heo HY, Wang X, Chen M, Lu H, Li H, Zhou J. Assessment of Glioma Response to Radiotherapy Using Multiple MRI Biomarkers with Manual and Semiautomated Segmentation Algorithms. J Neuroimaging. 2016;6:626-634.

123. Ravi H, Liu P, Peng SL, Liu H, Lu H. Simultaneous multi-slice (SMS) acquisition enhances the sensitivity of hemodynamic mapping using gas challenges. NMR Biomed. 2016;29:1511-1518.

122. Chapman SB, Aslan S, Spence JS, Keebler MW, DeFina LF, Didehbani N, Perez AM, Lu H, D'Esposito, M. Distinct Brain and Behavioral Benefits from Cognitive vs. Physical Training: A Randomized Trial in Aging Adults. Front Hum Neurosci. 2016;10:338.   

121. Zheng G, Wen J, Lu H, Lou Y, Pan Z, Liu W, Liu H, Li X, Zhang Z, Chen H, Kong X, Luo S, Jiang X, Liu Y, Zhang Z, Zhang LJ, Lu GM. Elevated global cerebral blood flow, oxygen extraction fraction and unchanged metabolic rate of oxygen in young adults with end-stage renal disease: an MRI study. Eur Radiol. 2016;26(6):1732-1741.

120. Song Z, McDonough IM, Liu P, Lu H, Park DC. Cortical amyloid burden and age moderate hippocampal activity in cognitively-normal adult. NeuroImage: Clinical. 2016;12:78-84.

119. Liu P, Chalak L, Krishnamurthy LC, Mir I, Peng S, Huang H, Lu H. T1 and T2 values of human neonatal blood at 3T: dependence on hematocrit, oxygenation and temperature. Magn Reson Med. 2016;75(4):1730-5.

118. Puzziferri N, Zigman JM, Thomas BP, Mihalakos P, Gallagher R, Carmody T, Lu H, Tamminga CA. Brain imaging demonstrates a reduced neural impact of eating in obesity. Obesity. 2016;24(4):829-836.   

117. Jordan LC, Gindville MC, Scott AO, Juttukonda M, Strother MK, Kassim AK, Chen SC, Lu H, Pruthi S, Shyr Y, Donahue MJ. Noninvasive imaging of oxygen extraction fraction in adults with sickle cell anemia. Brain. 2016;139(Pt 3):738-750.  

116. Ravi H, Thomas BP, Peng SL, Liu H, Lu H. On the optimization of imaging protocol for the mapping of cerebrovascular reactivity. J Magn Reson Imaging. 2016;43(3):661-8.   

115. Krishnamurthy LC, Mao D, King KS, Lu H. Correction and optimization of a T2-based approach to map blood oxygenation in small cerebral veins. Magn Reson Med. 2016;75(3):1100-1109.

114. Liu P, Dimitrov I, Andrews T, Crane DE, Dariotis JK, Desmond J, Dumas J, Gilbert G, Kumar A, Maclntosh BJ, Tucholka A, Yang S, Xiao G, Lu H. Multi-site evaluations of a T2-Relaxation-Under-Spin-Tagging (TRUST) MRI technique to measure brain oxygenation. Magn Reson Med. 2016;75(2):680-687.

113. Olvet DM, Delaparte L, Yeh FC, DeLorenzo C, McGrath PJ, Weissman MM, Adams P, Fava M, Deckersbach T, McInnis MG, Carmody TJ, Cooper CM, Kurian BT, Lu H, Toups MS, Trivedi MH, Parsey RV. A COMPREHENSIVE EXAMINATION OF WHITE MATTER TRACTS AND CONNECTOMETRY IN MAJOR DEPRESSIVE DISORDER. Depress Anxiety. 2016;33(1):56-65.   

112. Schmid S, Teeuwisse WM, Lu H, van Osch MJ. Time-efficient determination of spin compartments by time-encoded pCASL T2-relaxation-under-spin-tagging and its application in hemodynamic characterization of the cerebral border zones. Neuroimage. 2015;123:72-9.

111. Chawla S, Ge Y, Lu H, Marshall O, Soher BJ, Gonen O. Whole-Brain N-Acetylaspartate Concentration is Preserved During Mild Hypercapnia Challenge. AJNR Am J Neuroradiol. 2015;36(11):2055-2061.

110. Wang GZ, Belgard TG, Mao D, Chen L, Berto S, Preuss TM, Lu H, Geschwind DH, Konopka G. Correspondence between Resting-State Activity and Brain Gene Expression. Neuron. 2015;88(4):659-66.

109. Adinoff B, Gu H, Merrick C, McHugh M, Jeon-Slaughter H, Lu H, Yang Y, Stein EA. Basal hippocampal activity and its functional connectivity predicts cocaine relapse. Biol Psychiatry. 2015;78(7):496-504.

108. Marshall O, Uh J, Lurie Dl, Lu H, Milham MP, Ge Y. The influence of mild carbon dioxide on brain functional homotopy using resting-state fMRI. Hum Brain Mapp. 2015;36(10):3912-3921.

107. Peng S, Su P, Wang F, Cao Y, Zhang R, Lu H, Liu, P. Optimization of phase-contrast MRI for the quantification of whole-brain cerebral blood flow. J Magn Reson Imaging. 2015;42(4):1126-33.

106. Iscan Z, Jin TB, Kendrick A, Szeglin B, Lu H, Trivedi M, Fava M, McGrath PJ, Weissman M, Kurian BT, Adams P, Weyandt S, Toups M, Carmody T, McInnis M, Cusin C, Cooper C,  Oquendo M, Parsey RV, DeLorenzo C. Test-Retest Reliability of FreeSurfer Measurements Within and Between Sites: Effects of Visual Approval Process. Hum Brain Mapp. 2015;36(9):3472-3485.

105. Pinkham AE, Liu P, Lu H, Kriegsman M, Simpson C, Tamminga C. Amygdala hyperactivity at rest in paranoid individuals with schizophrenia. Am J Psychiatry, 2015;172(8):784-792. 

104. Sheng M, Lu H, Liu P, Thomas BP, McAdams CJ. Cerebral perfusion differences in women currently with and recovered from anorexia nervosa. Psychiatry Res. 2015;232(2):175-183.

103. Tarumi T, de Jong D, Zhu D, Tseng B, Liu J, Hill C, Riley J, Womack K, Kerwin D, Lu H, Cullum M, Zhang R. Central artery stiffness, baroreflex sensitivity, and brain white matter neuronal fiber integrity in older adults. Neuroimage. 2015;110:162-170. 

102. Xu F, Liu P, Pekar J, Lu H. Does acute caffeine ingestion alter brain metabolism in young adults? Neuroimage. 2015;110:39-47.  

101. Brown E, Jeon-Slaughter H, Lu H, Jamadar R, Issac S, Shad M, Denniston D, Tamminga C, Nakamura A, Thomas B. Hippocampal volume in healthy controls given 3-day stress doses of hydrocortisone. Neuropsychopharmacology. 2015;40:1216-1221.

100. Gopal KV, Thomas BP, Mao D, Lu H. Efficacy of carnitine in treatment of tinnitus: evidence from audiological and MRI measures-a case study. J Am Acad Audiol. 2015;26(3):311-324.  

99. Chapman SB, Aslan S, Spence JS, Hart JJ Jr, Bartz EK, Didehbani N, Keebler MW, Gardner CM, Strain JF, Defina LF, Lu H. Neural mechanisms of brain plasticity with complex cognitive training in healthy seniors. Cereb Cortex. 2015;25(2):396-405.

98. Xu F, Liu P, Pascual JM, Xiao G, Huang H, Lu H. Acute effect of glucose on cerebral blood flow, blood oxygenation, and oxidative metabolism. Hum Brain Mapp. 2015;36(2):707-716.

97. Ge Y, Marshall O, Lu H. Intracranial relationship between arterioles and venules size--reply. JAMA Neurol. 2015;72(1):124-5.  

96. Alsop DC, Detre JA, Golay X, Günther M, Hendrikse J, Hernandez-Garcia L, Lu H, Macintosh BJ, Parkes LM, Smits M, van Osch MJ, Wang DJ, Wong EC, Zaharchuk G. Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med. 2015;73(1):102-116.

95. Lu H, Liu P, Yezhuvath US, Cheng Y, Marshall O, Ge Y. MRI mapping of cerebrovascular reactivity via gas inhalation challenges. J Vis Exp. 2014;94.

94. Liu P, Chalak LF, Lu H. Non-invasive assessment of neonatal brain oxygen metabolism: A review of newly available techniques. Early Hum Dev. 2014;90(10):695-701.

93. Marshall O, Lu H, Brisset JC, Xu F, Liu P, Herbert J, Grossman RI, Ge Y. Impaired cerebrovascular reactivity in multiple sclerosis. JAMA Neurol. 2014;71(10):1275-1281. 

92. Pascual JM, Liu P, Mao D, Kelly DI, Hernandez A, Sheng M, Good LB, Ma Q, Marin-Valencia I, Zhang X, Park JY, Hynan LS, Stavinoha P, Roe CR, Lu H. Triheptanoin for glucose transporter type I deficiency (G1D): modulation of human ictogenesis, cerebral metabolic rate, and cognitive indices by a food supplement. JAMA Neurol. 2014;71(10):1255-1265.  

91. Peng SL, Dumas JA, Park DC, Liu P, Filbey FM, McAdams CJ, Pinkham AE, Adinoff B, Zhang R, Lu H. Age-related increase of resting metabolic rate in the human brain. Neuroimage. 2014;98:176-183.

90. Krishnamurthy LC, Liu P, Xu F, Uh J, Dimitrov I, Lu H. Dependence of blood T(2) on oxygenation at 7 T: in vitro calibration and in vivo application. Magn Reson Med. 2014;71(6):2035-2042.

89. Liu P, Lu H, Filbey FM, Tamminga CA, Cao Y, Adinoff B. MRI assessment of cerebral oxygen metabolism in cocaine-addicted individuals: hypoactivity and dose dependence. NMR Biomed. 2014;27(6):726-732.

88. Liu P, Lu H, Filbey FM, Pinkham AE, McAdams CJ, Adinoff B, Daliparthi V, Cao Y. Automatic and reproducible positioning of phase-contrast MRI for the quantification of global cerebral blood flow. PLoS One. 2014;9(5):e95721.

87. Liu J, Zhu YS, Khan MA, Brunk E, Martin-Cook K, Weiner MF, Cullum CM, Lu H, Levine BD, Diaz-Arrastia R, Zhang R. Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment. Alzheimers Dement. 2014;10(2):162-170. 

86. Krishnamurthy LC, Liu P, Ge Y, Lu H. Vessel-specific quantification of blood oxygenation with T2 -relaxation-under-phase-contrast MRI. Magn Reson Med. 2014;71(3):978-989. 

85. Liu P, Huang H, Rollins N, Chalak LF, Jeon T, Halovanic C, Lu H. Quantitative assessment of global cerebral metabolic rate of oxygen (CMRO2) in neonates using MRI. NMR Biomed. 2014;27(3):332-340.

84. Thomas BP, Liu P, Park DC, van Osch MJ, Lu H. Cerebrovascular reactivity in the brain white matter: magnitude, temporal characteristics, and age effects. J Cereb Blood Flow Metab. 2014;34(2):242-247.  

83. Miao X, Gu H, Yan L, Lu H, Wang DJ, Zhou XJ, Zhuo Y, Yang Y. Detecting resting-state brain activity by spontaneous cerebral blood volume fluctuations using whole brain vascular space occupancy imaging. Neuroimage. 2014;84:575-584.

82. Thomas BP, Liu P, Aslan S, King KS, van Osch MJ, Lu H. Physiologic underpinnings of negative BOLD cerebrovascular reactivity in brain ventricles. Neuroimage. 2013;83:505-512.

81. Tseng BY, Gundapuneedi T, Khan MA, Diaz-Arrastia R, Levine BD, Lu H, Huang H, Zhang R. White matter integrity in physically fit older adults. Neuroimage. 2013;82:510-516. 

80.  Chapman SB, Aslan S, Spence JS, Defina LF, Keebler MW, Didehbani N, Lu H. Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging. Front Aging Neurosci. 2013;5:75.

79. Ivleva EI, Bidesi AS, Keshavan MS, Pearlson GD, Meda SA, Dodig D, Moates AF, Lu H, Francis AN, Tandon N, Schretlen DJ, Sweeney JA, Clementz BA, Tamminga CA. Gray matter volume as an intermediate phenotype for psychosis: Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP). Am J Psychiatry. 2013;170(11):1285-1296.

78. Thomas BP, Yezhuvath US, Tseng BY, Liu P, Levine BD, Zhang R, Lu H. Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO2. J Magn Reson Imaging. 2013;38(5):1177-1183. 

77. Tseng BY, Uh J, Rossetti HC, Cullum CM, Diaz-Arrastia RF, Levine BD, Lu H, Zhang R. Masters athletes exhibit larger regional brain volume and better cognitive performance than sedentary older adults. J Magn Reson Imaging. 2013;38(5):1169-1176.  

76. Hutchison JL, Lu H, Rypma B. Neural mechanisms of age-related slowing: the ΔCBF/ΔCMRO2 ratio mediates age-differences in BOLD signal and human performance. Cereb Cortex. 2013;23(10):2337-2346.

75. Almeida JR, Mourao-Miranda J, Aizenstein HJ, Versace A, Kozel FA, Lu H, Marquand A, LaBarbara EJ, Brammer M, Trivedi M, Kupfer DJ, Phillips ML. Pattern recognition analysis of anterior cingulate cortex blood flow to classify depression polarity. Br J Psychiatry. 2013;203(3):310-311. 

74. Brown ES, Lu H, Denniston D, Uh J, Thomas BP, Carmody TJ, Auchus RJ, Diaz-Arrastia R, Tamminga C. A randomized, placebo-controlled proof-of-concept, crossover trial of phenytoin for hydrocortisone-induced declarative memory changes. J Affect Disord. 2013;150(2):551-558.  

73. Liu P, Hebrank AC, Rodrigue KM, Kennedy KM, Park DC, Lu H. A comparison of physiologic modulators of fMRI signals. Hum Brain Mapp. 2013;34(9):2078-2088. 

72. Newsome MR, Scheibel RS, Mayer AR, Chu ZD, Wilde EA, Hanten G, Steinberg JL, Lin X, Li X, Merkley TL, Hunter JV, Vasquez AC, Cook L, Lu H, Vinton K, Levin HS. How functional connectivity between emotion regulation structures can be disrupted: preliminary evidence from adolescents with moderate to severe traumatic brain injury. J Int Neuropsychol Soc. 2013;19(8):911-924. 

71. Liu P, Hebrank AC, Rodrigue KM, Kennedy KM, Section J, Park DC, Lu H. Age-related differences in memory-encoding fMRI responses after accounting for decline in vascular reactivity. Neuroimage. 2013;78:415-425.

70. Tung KC, Uh J, Mao D, Xu F, Xiao G, Lu H. Alterations in resting functional connectivity due to recent motor task. Neuroimage. 2013;78:316-324.  

69. Lu H, Hua J, van Zijl PC. Noninvasive functional imaging of cerebral blood volume with vascular-space-occupancy (VASO) MRI. NMR Biomed. 2013;26(8):932-48.

68. Ewing J, Lu H. MRI measures of cerebral physiology. NMR Biomed. 2013;26(8):885-886.

67. Hutchison JL, Shokri-Kojori E, Lu H, Rypma B. A BOLD perspective on age-related neurometabolic-flow coupling and neural efficiency changes in human visual cortex. Front Psychol. 2013;4:244.   

66. Hart J Jr, Kraut MA, Womack KB, Strain J, Didehbani N, Bartz E, Conover H, Mansinghani S, Lu H, Cullum CM. Neuroimaging of cognitive dysfunction and depression in aging retired National Football League players: a cross-sectional study. JAMA Neurol. 2013;70(3):326-335.

65. Liu P, Xu F, Lu H. Test-retest reproducibility of a rapid method to measure brain oxygen metabolism. Magn Reson Med. 2013;69(3):675-681.  

64. Xu F, Liu P, Pascual JM, Xiao G, Lu H. Effect of hypoxia and hyperoxia on cerebral blood flow, blood oxygenation, and oxidative metabolism. J Cereb Blood Flow Metab. 2012;32(10):1909-1918.  

63. Jeon T, Mishra V, Uh J, Weiner M, Hatanpaa KJ, White CL 3rd, Zhao YD, Lu H, Diaz-Arrastia R, Huang H. Regional changes of cortical mean diffusivities with aging after correction of partial volume effects. Neuroimage. 2012;62(3):1705-1716.   

62. van Zijl PC, Hua J, Lu H. The BOLD post-stimulus undershoot, one of the most debated issues in fMRI, Neuroimage. 2012;62(2):1092-1102. 

61. Lu H, van Zijl PC. A review of the development of Vascular-Space-Occupancy (VASO) fMRI. Neuroimage. 2012;62(2):736-742.  

60. Xu F, Uh J, Liu P, Lu H. On improving the speed and reliability of T2-relaxation-under-spin-tagging (TRUST) MRI. Magn Reson Med. 2012;68(1):198-204.  

59. Newsome MR, Scheibel RS, Chu Z, Hunter JV, Li X, Wilde EA, Lu H, Wang ZJ, Lin X, Steinberg JL, Vasquez AC, Cook L, Levin HS. The relationship of resting cerebral blood flow and brain activation during a social cognition task in adolescents with chronic moderate to severe traumatic brain injury: a preliminary investigation. Int J Dev Neurosci. 2012;30(3):255-266.  

58. Liu P, Uh J, Devous MD, Adinoff B, Lu H. Comparison of relative cerebral blood flow maps using pseudo-continuous arterial spin labeling and single photon emission computed tomography. NMR Biomed. 2012;25(5):779-786.  

57. Tao R, Calley CS, Hart J, Mayes TL, Nakonezny PA, Lu H, Kennard BD, Tamminga CA, Emslie GJ. Brain activity in adolescent major depressive disorder before and after fluoxetine treatment. Am J Psychiatry. 2012;169(4):381-388. 

56. Ge Y, Zhang Z, Lu H, Tang L, Jaggi H, Herbert J, Babb JS, Rusinek H, Grossman RI. Characterizing brain oxygen metabolism in patients with multiple sclerosis with T2-relaxation-under-spin-tagging MRI. J Cereb Blood Flow Metab. 2012;32(3):403-412. 

55. Lu H, Xu F, Grgac K, Liu P, Qin Q, van Zijl P. Calibration and validation of TRUST MRI for the estimation of cerebral blood oxygenation. Magn Reson Med. 2012;67(1):42-49.   

54. Yezhuvath US, Uh J, Cheng Y, Martin-Cook K, Weiner M, Diaz-Arrastia R, van Osch M, Lu H. Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's disease., Neurobiol Aging. 2012;33(1):75-82.

53. Lu H, Hutchison J, Xu F, Rypma B. The relationship between M in “calibrated fMRI” and the physiologic modulators of fMRI. Open Neuroimag J. 2011;5:112-119.

52. Lin AL, Lu H, Fox PT, Duong TQ. Cerebral blood volume measurements - Gd_DTPA vs. VASO - and their relationship with cerebral blood flow in activated human visual cortex., Open Neuroimag J. 2011;5:90-95.  

51. Lu H, Xu F, Rodrigue KM, Kennedy KM, Cheng Y, Flicker B, Hebrank AC, Uh J, Park DC. Alterations in cerebral metabolic rate and blood supply across the adult lifespan. Cereb Cortex. 2011;21(6):1426-1434.  

50. van Osch MJ, Lu H. Arterial spin labeling perfusion MRI in Alzheimer’s Disease, Curr Med Imaging Rev. 2011;7:62-72. 

49. Aslan S, Huang H, Uh J, Mishra V, Xiao G, van Osch MJ, Lu H. White matter cerebral blood flow is inversely correlated with structural and functional connectivity in the human brain. Neuroimage. 2011;56(3):1145-1153.  

48. Kozel FA, Rao U, Lu H, Nakonezny PA, Grannemann B, McGregor T, Croarkin PE, Mapes KS, Tamminga CA, Trivedi MH. Functional connectivity of brain structures correlates with treatment outcome in major depressive disorder. Front Psychiatry. 2011;2:7.   

47. Uh J, Lin AL, Lee K, Liu P, Fox P, Lu H. Validation of VASO cerebral blood volume measurement with positron emission tomography. Magn Reson Med. 2011;65(3):744-749.  

46. Liu P, Aslan S, Li X, Buhner DM, Spence JS, Briggs RW, Haley RW, Lu H. Perfusion deficit to cholinergic challenge in veterans with Gulf War Illness. Neurotoxicology. 2011;32(2):242-246.   

45. Xu F, Uh J, Brier MR, Hart J Jr, Yezhuvath US, Gu H, Yang Y, Lu H. The influence of carbon dioxide on brain activity and metabolism in conscious humans. J Cereb Blood Flow Metab. 2011;31(1):58-67.  

44. Liu P, Uh J, Lu H. Determination of spin compartment in arterial spin labeling MRI. Magn Reson Med. 2011;65(1):120-127.  

43. Uh J, Lewis-Amezcua K, Martin-Cook K, Cheng Y, Weiner M, Diaz-Arrastia R, Devous M Sr, Shen D, Lu H. Cerebral blood volume in Alzheimer's disease and correlation with tissue structural integrity. Neurobiol Aging. 2010;31(12):2038-46.

42. Choi C, Ghose S, Uh J, Patel A, Dimitrov IE, Lu H, Douglas D, Ganji S. Measurement of N-acetylaspartylglutamate in the human frontal brain by 1H-MRS at 7 T. Magn Reson Med. 2010;64(5):1247-1251.   

41. Aslan S, Lu H. On the sensitivity of ASL MRI in detecting regional differences in cerebral blood flow. Magn Reson Imaging. 2010;28(7):928-935. 

40. Uh J, Yezhuvath U, Cheng Y, Lu H. In vivo vascular hallmarks of diffuse leukoaraiosis. J Magn Reson Imaging. 2010;32(1):184-190.   

39. Aslan S, Xu F, Wang PL, Uh J, Yezhuvath US, van Osch M, Lu H. Estimation of labeling efficiency in pseudocontinuous arterial spin labeling. Magn Reson Med. 2010;63(3):765-771. 

38. Newsome MR, Scheibel RS, Hanten G, Chu Z, Steinberg JL, Hunter JV, Lu H, Vasquez AC, Li X, Lin X, Cook L, Levin HS. Brain activation while thinking about the self from another person's perspective after traumatic brain injury in adolescents. Neuropsychology. 2010;24(2):139-147.  

37. Lu H, Yezhuvath US, Xiao G. Improving fMRI sensitivity by normalization of basal physiologic state. Hum Brain Mapp. 2010;31(1):80-87.   

36. Petersen ET, Mouridsen K, Golay X; all named co-authors of the QUASAR test-retest study. The QUASAR reproducibility study, Part II: Results from a multi-center Arterial Spin Labeling test-retest study. Neuroimage. 2010;49(1):104-113.  

35. Yezhuvath US, Lewis-Amezcua K, Varghese R, Xiao G, Lu H. On the assessment of cerebrovascular reactivity using hypercapnia BOLD MRI. NMR Biomed. 2009;22(7):779-786.   

34. Xu, F., Ge, Y., Lu, H. Noninvasive quantification of whole-brain cerebral metabolic rate of oxygen (CMRO2) by MRI. Magn Reson Med. 2009;62(1):141-148.  

33. Uh J, Lewis-Amezcua K, Varghese R, Lu H. On the measurement of absolute cerebral blood volume (CBV) using vascular-space-occupancy (VASO) MRI. Magn Reson Med. 2009;61(3):659-667.

32. Jensen JH, Szulc K, Hu C, Ramani A, Lu H, Xuan L, Falangola MF, Chandra R, Knopp EA, Schenck J, Zimmerman EA, Helpern JA. Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain. Magn Reson Med. 2009;61(2):481-485. 

31. Lin AL, Fox PT, Yang Y, Lu H, Tan LH, Gao JH. Time-dependent correlation of cerebral blood flow with oxygen metabolism in activated human visual cortex as measured by fMRI. Neuroimage. 2009;44(1):16-22. 

30. Lin AL, Fox PT, Yang Y, Lu H, Tan LH, Gao JH. Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF. Magn Reson Med. 2008;60(2):380-389.  

29. Lu H, Zhao C, Ge Y, Lewis-Amezcua K. Baseline blood oxygenation modulates response amplitude: Physiologic basis for intersubject variations in functional MRI signals. Magn Reson Med. 2008;60(2):364-372.

28. Lu H, Ge Y. Quantitative evaluation of oxygenation in venous vessels using T2-Relaxation-Under-Spin-Tagging MRI. Magn Reson Med. 2008;60(2):357-63.  

27. Newsome MR, Steinberg JL, Scheibel RS, Troyanskaya M, Chu Z, Hanten G, Lu H, Lane S, Lin X, Hunter JV, Vasquez C, Zientz J, Li X, Wilde EA, Levin HS. Effects of traumatic brain injury on working memory-related brain activation in adolescents. Neuropsychology. 2008;22(4):419-425. 

26. Lu H, Pollack E, Young R, Babb JS, Johnson G, Zagzag D, Carson R, Jensen JH, Helpern JA, Law M. Predicting grade of cerebral glioma using vascular-space occupancy MR imaging. AJNR Am J Neuroradiol. 2008;29(2):373-378.

25. Lu H, Law M, Ge Y, Hesseltine SM, Rapalino O, Jensen JH, Helpern JA. Quantitative measurement of spinal cord blood volume in humans using vascular-space-occupancy MRI. NMR Biomed. 2008;21(3):226-232.

24. Ge Y, Jensen JH, Lu H, Helpern JA, Miles L, Inglese M, Babb JS, Herbert J, Grossman RI. Quantitative assessment of iron accumulation in the deep gray matter of multiple sclerosis by magnetic field correlation imaging. AJNR Am J Neuroradiol. 2007;28(9):1639-1644.

23. Thakur PH, Lu H, Hsiao SS, Johnson KO. Automated optimal detection and classification of neural action potentials in extra-cellular recordings. J Neurosci Methods. 2007;162(1-2):364-376. 

22. Prabhakaran V, Raman SP, Grunwald MR, Mahadevia A, Hussain N, Lu H, Van Zijl PC, Hillis AE. Neural substrates of word generation during stroke recovery: the influence of cortical hypoperfusion. Behav Neurol. 2007;18(1):45-52.

21. Donahue MJ, Lu H, Jones CK, Edden RA, Pekar JJ, van Zijl PC. Theoretical and experimental investigation of the VASO contrast mechanism. Magn Reson Med. 2006;56(6):1261-1273. 

20. Jensen JH, Lu H, Inglese M. Microvessel density estimation in the human brain by means of dynamic contrast-enhanced echo-planar imaging. Magn Reson Med. 2006;56(5):1145-1150.

19. Donahue MJ, Lu H, Jones CK, Pekar JJ, van Zijl PC. An account of the discrepancy between MRI and PET cerebral blood flow measures. A high-field MRI investigation. NMR Biomed. 2006;19(8):1043-1054.

18. Lu H, Donahue MJ, van Zijl PC. Detrimental effects of BOLD signal in arterial spin labeling fMRI at high field strength. Magn Reson Med. 2006;56(3):546-552. 

17. Strouse JJ, Cox CS, Melhem ER, Lu H, Kraut MA, Razumovsky A, Yohay K, van Zijl PC, Casella JF. Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA). Blood. 2006;108(1):379-381.  

16. Jensen JH, Chandra R, Ramani A, Lu H, Johnson G, Lee SP, Kaczynski K, Helpern JA. Magnetic field correlation imaging. Magn Reson Med. 2006;55(6):1350-1361.  

15. Lu H, Jensen JH, Ramani A, Helpern JA. Three-dimensional characterization of non-gaussian water diffusion in humans using diffusion kurtosis imaging. NMR Biomed. 2006;19(2):236-247.  

14. Gu H, Lu H, Ye FQ, Stein EA, Yang Y. Noninvasive quantification of cerebral blood volume in humans during functional activation. Neuroimage. 2006;30(2):377-387. 

13. van Laar PJ, Hendrikse J, Golay X, Lu H, van Osch MJ, van der Grond J. In vivo flow territory mapping of major brain feeding arteries. Neuroimage. 2006;29(1):136-144.

12. Lu H, Law M, Johnson G, Ge Y, van Zijl PC, Helpern JA. Novel approach to the measurement of absolute cerebral blood volume using vascular-space-occupancy magnetic resonance imaging. Magn Reson Med. 2005;54(6):1403-1411.

11. Lu H, Basso G, Serences JT, Yantis S, Golay X, van Zijl PC. Retinotopic mapping in the human visual cortex using vascular space occupancy-dependent functional magnetic resonance imaging. Neuroreport. 2005;16(15):1635-1640.

10. Lu H, Nagae-Poetscher LM, Golay X, Lin D, Pomper MG, van Zijl PC. Routine clinical brain MRI sequences for use at 3.0 Tesla. J Magn Reson Imaging. 2005;22(1):13-22.

9. Jensen JH, Helpern JA, Ramani A, Lu H, Kaczynski K. Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med. 2005;53(6):1432-1440.  

8. Lu H, van Zijl PC Experimental measurement of extravascular parenchymal BOLD effects and tissue oxygen extraction fractions using multi-echo VASO fMRI at 1.5 and 3.0 T. Magn Reson Med. 2005;53(4):808-816.

7. Lu H, Clingman C, Golay X, van Zijl PC. Determining the longitudinal relaxation time (T1) of blood at 3.0 Tesla. Magn Reson Med. 2004;52(3):679-682.

6. Lu H, Golay X, Pekar JJ, van Zijl PC. Sustained post-stimulus elevation in cerebral oxygen utilization following vascular recovery. J Cereb Blood Flow Metab. 2004;24(7):764-770. 

5. Hendrikse J, van der Grond J, Lu H, van Zijl PC, Golay X. Flow territory mapping of the cerebral arteries with regional perfusion MRI. Stroke. 2004;35(4):882-887.

4. Lu H, van Zijl PC, Hendrikse J, Golay X. Multiple acquisitions with global inversion cycling (MAGIC): a multislice technique for vascular-space-occupancy dependent fMRI. Magn Reson Med. 2004;51(1):9-15.  

3. Hendrikse J, Lu H, van der Grond J, van Zijl PC, Golay X. Measurements of cerebral perfusion and arterial hemodynamics during visual stimulation using TURBO-TILT. Magn Reson Med. 2003;50(2):429-433. 

2. Lu H, Golay X, Pekar JJ, van Zijl PC. Functional magnetic resonance imaging based on changes in vascular space occupancy. Magn Reson Med. 2003;50(2):263-274.  

1. Lu H, Golay X, van Zijl PC. Intervoxel heterogeneity of event-related functional magnetic resonance imaging responses as a function of T(1) weighting. Neuroimage. 2002;17(2):943-955. 

 

 

 

Publications

Russell H. Morgan Department of Radiology

Hanzhang Lu Lab